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Cancer Genetics

ONCOSEQ DNALAB HERITAGE CANCER PANELS

ONCOSEQ DNALAB COMPREHENSIVE HERITAGE CANCER PANEL

Today, genetic tests for cancer are personalized; It is carried out for the diagnosis, follow-up, prognosis and treatment of oncological diseases, choosing the right drug and determining the risk of familial cancer. Disorders that cause cancer; Gene mutations, increased gene expression, deletions, translocations and similar anomalies are detected by genetic tests. Some DNA mutations are hereditary and are passed down through your family. This means that when you are born, mutations are in all your cells. These mutations can greatly increase the risk of certain cancers. They cause most of the cancers that occur in various members of some families, and often people with the genetic disorder can get cancer at a younger age.

WHY CHOOSE CENTOGENE?
  • Test
    Hereditary Cancer Tests
  • Method
    Next Generation Sequencing
  • Analysis Time
    21 Days
  • Sample Type
    Blood (with EDTA)
  • Storage Conditions
    1 day at +4°C
  • Transport Conditions
    On the same day at +4°C
  • Rejection Criteria
    Hemolyzed, Lipemic, Icteric samples are not accepted

Gene Table

Comprehensive Hereditary Cancer Panel (164 Genes)
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AIP ALK ANKRD26 APC ATM
ATR AXIN2 BAP1 BARD1 BLM
BMPR1A BRAF BRCA1 BRCA2 BRIP1
BUB1B CBL CD70 CDC73 CDH1
CDK4 CDKN1B CDKN1C CDKN2A CEBPA
CEP57 CHEK2 CTNNA1 CYLD DDB2
DDX41 DICER1 DIS3L2 DKC1 EFL1
EGFR ELANE EPCAM ERCC1 ERCC2
ERCC3 ERCC4 ERCC5 ETV6 EXO1
EXT1 EXT2 EZH2 FAM111B FANCA
FANCB FANCC FANCD2 FANCE FANCF
FANCG FANCI FANCL FANCM FH
FLCN GALNT12 GATA2 GPC3 GPR101
GREM1 HAVCR2 HNF1 HNF1A HOXB13
HRAS IKZF1 IRS4 KIF1B KIT
KITLG KRAS LZTR1 MAP2K1 MAP2K2
MAX MEN1 MET MITF MLH1
MLH3 MRE11A MSH2 MSH3 MSH6
MUTYH NBN NF1 NF2 NRAS
NSD1 NSUN2 NTHL1 PALB2 PAX5
PDGFRA PHOX2B PIK3CA PMS1 PMS2
POLD1 POLE POLH POT1 PPM1D
PRF1 PRKAR1A PTCH1 PTEN PTPN11
RAD50 RAD51C RAD51D RAF1 RASA2
RB1 RECQL RECQL4 REST RET
RHBDF2 RIT1 RPS20 RRAS RUNX1
SAMD9 SAMD9L SBDS SDHA SDHAF2
SDHB SDHC SDHD SHOC2 SLX4
SMAD4 SMARCA4 SMARCB1 SMARCE1 SOS1
SOS2 SPRED1 SRP72 STK11 SUFU
TERC TERT TINF2 TMEM127 TP53
TRIP13 TSC1 TSC2 VHL WRN
WT1 XPA XPC XRCC2

Hereditary Breast and Ovarian Cancer (27 Genes)
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ATM BARD1 BLM BRCA1 BRCA2
BRIP1 CDH1 CHEK2 DICER1 EPCAM
FANCM MLH1 MRE11 MSH2 MSH6
NBN NF1 PALB2 PMS2 PTEN
RAD50 RAD51C RAD51D SMARCA4 STK11
TP53 XRCC2

Hereditary Breast Cancer High Risk Panel (7 Genes)
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BRCA1 BRCA2 CDH1 PALB2 PTEN STK11 TP53

Hereditary Cancer High Risk Panel (27 Genes)
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APC ATM BAP1 BMPR1A BRCA1 BRCA2 CDH1 CDK4 CDKN2A
CHEK2 EPCAM MEN1 MLH1 MSH2 MSH6 MUTYH PALB2 PMS2
POLD1 PTEN RAD51C RAD51D RET SMAD4 STK11 TP53 VHL

Hereditary Colorectal Cancer Panel (19 Genes)
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APC AXIN2 BLM BMPR1A EPCAM GALNT12 GREM1 MLH1 MSH2 MSH3
MSH6 MUTYH NTHL1 PMS2 POLD1 PTEN SMAD4 STK11 TP53

Hereditary Endocrine Cancer Panel (22 Genes)
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AIP APC CDC73 CDKN1B DICER1 FH MAX MEN1 MET NF1 PRKAR1A
PTEN RET SDHA SDHAF2 SDHB SDHC SDHD TMEM127 TP53 VHL WRN

Hereditary Gastrointestinal Cancer Panel (40 Genes)
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APC ATM AXIN2 BLM BMPR1A
BRCA1 BRCA2 BUB1B CDH1 CDKN2A
EPCAM FANCC GALNT12 GREM1 KIT
MEN1 MLH1 MSH2 MSH3 MSH6
MUTYH NF1 NTHL1 PALB2 PDGFRA
SDHC SDHD SMAD4 SMARCB1 STK11
TMEM127 TP53 TSC1 TSC2 VHL
PMS2 POLD1 PTEN RHBDF2 SDHB

Hereditary Leukemia Panel (36 Genes)
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ANKRD26 ATM BLM BRAF BRCA1
BRCA2 CBL CDKN2A CEBPA DKC1
EPCAM ETV6 FANCA GATA2 HRAS
IKZF1 KRAS MAP2K1 MAP2K2 MLH1
MSH2 MSH6 NBN NF1 NRAS
PAX5 PMS2 PTPN11 RUNX1 SAMD9
SOS1 SRP72 TERC TERT TINF2 TP53

Hereditary Lung Cancer Panel (4 Genes)
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BRCA2 CDKN2A EGFR TP53

Hereditary Melanoma and Skin Cancer Panel (18 Genes)
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BAP1 BRCA1 BRCA2 CDK4 CDKN2A DDB2
ERCC2 ERCC3 ERCC4 ERCC5 MITF PTCH1
PTEN SUFU TP53 WRN XPA XPC

Hereditary Pancreatic Cancer Panel (22 Genes)
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APC ATM BMPR1A BRCA1 BRCA2
BUB1B CDKN2A EPCAM FANCC MEN1
MLH1 MSH2 MSH6 NF1 PALB2 PMS2
SMAD4 STK11 TP53 TSC1 TSC2 VHL

Hereditary Paraganglioma and Pheochromocytoma Panel (11 Genes)
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FH MAX NF1 RET SDHA
SDHAF2 SDHB SDHC SDHD TMEM127 VHL

Hereditary Pediatric Cancer Panel (65 Genes)
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ALK DIS3L2 MSH2 PTCH1 SMAD4
APC EPCAM MSH6 PTEN SMARCA4
AXIN2 EZH2 NBN PTPN11 SMARCB1
BAP1 FH NF1 RAF1 SOS1
BLM GATA2 NF2 RECQL4 STK11
BMPR1A GPC3 NRAS RET SUFU
BRAF HRAS NSD1 RUNX1 TMEM127
BUB1B KRAS NSUN2 SDHA TP53
CBL MAP2K1 PAX5 SDHAF2 TSC1
CDC73 MAP2K2 PHOX2B SDHB TSC2
CDKN1C MAX PMS2 SDHC VHL
CEBPA MEN1 PRF1 SDHD WRN
DICER1 MLH1 PRKAR1A SHOC2 WT1

Hereditary Renal Cancer Panel (25 Genes)
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BAP1 CDC73 CDKN1C DICER1 DIS3L2
EPCAM FH FLCN GPC3 MET
MLH1 MSH2 MSH6 PMS2 PTEN
SDHB SDHC SDHD SMARCA4 SMARCB1
TP53 TSC1 TSC2 VHL WT1

Tuberous Sclerosis Panel (2 Genes)
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TSC1 TSC2

Xeroderma Pigmentosum Panel (9 Genes)
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DDB2 ERCC1 ERCC2 ERCC3 ERCC4
ERCC5 POLH XPA XPC

Discover Your Genetic Heritage

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ONCOSEQ DNALAB - Cancer Genetics

PRIMIS - Non-Invasive Prenatal Test

Preimplantation Genetic Diagnosis - PGD

Whole Exome Sequencing

Clinical Exome Sequencing

Rare Diseases

Carrier Panels - SMARIS