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PREIMPLANTATION GENETIC DIAGNOSIS (PGD)

PREIMPLANTATION GENETIC DIAGNOSIS (PGD)

DNA Laboratuvarları In our Genetic Diseases Evaluation Center, numerical and structural chromosomal anomalies are detected using Next Generation Sequencing (NGS), Single Gene Diseases and HLA compatibility screenings, Next Generation Sequencing, Sanger Sequencing and Fragment Analysis techniques. We carry out these procedures with our expert physicians in their fields.

Preimplantation Genetic Diagnosis (PGD); It is the genetic testing of embryos before they are transferred to the mother’s uterus. PGT is recommended for couples who are at risk of having a genetic disease or anomaly. With the PGT test, only healthy embryos are transferred to the mother.

WHY CHOOSE CENTOGENE?
  • Case Evaluation
    Prospective parents meet with our Genetic Specialist to decide whether additional genetic testing of the couple or other family members is necessary.
  • PGD-M Test Preparation
    A family-specific PGT-M test is designed in our laboratory.
  • In Vitro Fertilization Center
    In vitro fertilization is performed and the resulting embryos are incubated.
  • Embryo Biopsy
    The embryologist carefully takes samples from each embryo.
  • PGD-M Test Phase
    After the samples taken by the embryologist are sent to our laboratory, the PGT-M test is performed and the results are shared with the In Vitro Fertilization Center.
  • Embryo Transfer
    The unaffected embryo is transferred, the remaining embryos can be frozen for future use.

Preimplantation Genetic Diagnosis-Aneuploidy Screening (PGT-A) is the process of screening embryos for aneuploidies (numerical chromosomal disorders) using various techniques.

If a couple’s close or distant relatives are known to have a single gene disease or a disorder caused by a change in a single gene, they may be at risk of having that genetic disorder in their unborn child. In single gene diseases, Preimplantation Genetic Diagnosis – Single Gene (PGT-M) is used to reduce the risk of transmission of such diseases.

Since healthy and unaffected embryos are transferred with PGT, it stands out as an important alternative to invasive prenatal diagnosis techniques (amniocentesis or chorionic villus). PGT-M and PGT-A save families from the difficult situation of terminating a pregnancy when invasive prenatal diagnosis yields negative results. PGT-M and PGT-A are the only tests that prevent the risk of giving birth to a child with the disease.

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Who Should Have Preimplantation Genetics?

  • Advanced mothers-to-be
  • Couples with a history of recurrent pregnancy loss
  • Couples with recurrent implantation failure
  • Advanced male infertility factor
  • Single gene diseases or disorders caused by single gene changes in close or distant relatives of the couple
  • In HLA compatibility screenings
  • Couples who have previously had children with genetic diseases,

Preimplantation Genetic Diagnosis Indications

  • Sex chromosome related diseases
  • Single gene diseases
  • HLA (Human leukocyte antigen) compatibility screening
  • Chromosomal disorders

The size and timing of the study to be carried out are determined after our Genetic Counseling Service, which will be given to the family for Preimplantation Genetic Test PGT-M in single gene diseases and HLA compatibility screening.

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Discover Your Genetic Heritage

You can contact us to get information about our genetic tests, consultancy services and more.

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ONCOSEQ DNALAB (Cancer Genetics)

PRIMIS Non-Invasive Prenatal Test

Preimplantation Genetic Diagnosis (PGD)

Whole Exome Sequencing

Clinical Exome Sequencing

Rare Diseases

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